In this research, the influence of the parameters of Metallic wires in the foam cores of sandwich panels as a reinforcement to improve the bending properties of sandwich panels has been investigated. In this regard, the three parameters including the number of wires (on a scale of 1, 2, and 3 wires), wire material (aluminum, iron, and steel) and their diameter (0.75, 1, and 1.5 mm) as the effective input parameters and specific bending strength and modulus of the structure have been selected as the output parameters of the design of experiment. In order to evaluate the parameters after validating the numerical model using the built prototype, an experiment has been designed using the Mini Tab software (Taguchi method) and simulation of the proposed tests has been carried out using the Abaqus software.The results showed that the optimal sample with priority of strength to weight includes three steel wires on each side, with the diameter of one millimeter. Also, with the increase in the number and diameter of the wires, the strength has increased, but this relationship is not always correct when assessing the strength to the weight of the sample. Increasing the mechanical properties of the wire increases the overall strength of the structure, so that the bending strength of the sandwich panel reinforced with three steel wires rises by about 43%, the bending modulus by about 80%, the specific strength by weight by 21%, and the special bending modulus by about 54%.